Post-operative radiotherapy for oral cavity squamous cell carcinoma: Review of the data guiding the selection and the delineation of post-operative target volumes

Evans, Mererid, Bonomo, Pierluigi, Chan, Po, Chua, Melvin L. K., Eriksen, Jesper Grau, Hunter, Keith, Jones, T. M., Laskar, Sarbani Ghosh, Maroldi, Roberto, O'Sullivan, Brian, Paterson, Claire, Tagliaferri, Luca, Tribius, Silke, Yom, Sue S. and Gregoire, Vincent 2025. Post-operative radiotherapy for oral cavity squamous cell carcinoma: Review of the data guiding the selection and the delineation of post-operative target volumes. Radiotherapy & Oncology 207 , 110880. 10.1016/j.radonc.2025.110880

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Abstract

To date, no consensus guidelines have been published that systematically guide delineation of primary and nodal Clinical Target Volumes (CTVs) in patients who require post-operative radiotherapy (PORT) for head and neck squamous cell carcinoma (HNSCC). As a result, significant individual, institutional and national variation exists in the way that CTVs are delineated in the post-operative setting, leading to considerable heterogeneity in radiotherapy treatment. A multi-disciplinary group of experts was convened by the European Society for Radiotherapy and Oncology (ESTRO), including radiation oncologists from Europe, North America and Asia, as well as surgery, radiology and pathology representatives. Oral cavity squamous cell carcinoma (OCSCC), where surgery followed by PORT is the standard of care, was first selected for focus. The indications for PORT, and the influence of tumour subsite and stage on post-operative treatment volumes, were considered with reference to current evidence, and clinical experience within the group. We present clear recommendations regarding the indications for PORT in OCSCC, and propose a new classification of lateralised and non-lateralised OCSCC, to help guide the delineation of post-operative nodal CTVs. The evidence and expert opinion summarised in this manuscript provides the background and context required to underpin new international consensus guidelines for the delineation of primary and nodal CTVs for OCSCC in the post-operative setting. [Abstract copyright: Copyright © 2025. Published by Elsevier B.V.]

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	0167-8140
Date of First Compliant Deposit:	30 April 2025
Date of Acceptance:	1 April 2025
Last Modified:	30 Apr 2025 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/177978

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