Modulation of humoral immunity by γδ T cells: a potential adjuvant strategy for vaccination

Emery, Kirsty and Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348 2025. Modulation of humoral immunity by γδ T cells: a potential adjuvant strategy for vaccination. Murphy, Kenneth M. and Alt, Frederick W., eds. Advances in Immunology, Vol. 167. Elsevier, pp. 123-173. (10.1016/bs.ai.2025.05.001)

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Abstract

Vaccination is arguably the most effective intervention in reducing the impact of infectious diseases. However, many vaccines provide only partial or transient protection, prompting the need for more effective solutions based on our growing understanding of the pivotal role of CD4+ T follicular helper (Tfh) cells in humoral immunity and how they interact with B cells. Here we review how γδ T cells can boost antibody responses via crosstalk with both Tfh and B cells, which could lead to new adjuvant strategies to improve vaccination efficacy, achieve long-lasting protective immunity and prevent major infectious diseases of global importance.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Publisher:	Elsevier
ISBN:	9780443344954
Date of First Compliant Deposit:	27 May 2025
Last Modified:	31 Oct 2025 14:40
URI:	https://orca.cardiff.ac.uk/id/eprint/178532

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