The time-changed stochastic approach and fractionally integrated processes to model the actin-myosin interaction and dwell times

Leonenko, Nikolai ORCID: https://orcid.org/0000-0003-1932-4091 and Pirozzi, Enrica 2025. The time-changed stochastic approach and fractionally integrated processes to model the actin-myosin interaction and dwell times. Mathematical Biosciences and Engineering 22 (4) , pp. 1019-1054. 10.3934/mbe.2025037

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Abstract

We propose two stochastic models for the interaction between the myosin head and the actin filament, the physio-chemical mechanism triggering muscle contraction and that is not yet completely understood. We make use of the fractional calculus approach with the purpose of constructing non-Markov processes for models with $ memory. $ A time-changed process and a fractionally integrated process are proposed for the two models. Each of these includes memory effects in a different way. We describe such features from a theoretical point of view and with simulations of sample paths. Mean functions and covariances are provided, considering constant and time-dependent tilting forces by which effects of external loads are included. The investigation of the dwell time of such phenomenon is carried out by means of density estimations of the first exit time (FET) of the processes from a strip; this mimics the times of the Steps of the myosin head during the sliding movement outside a potential well due to the interaction with actin. For the case of time-changed diffusion process, we specify an equation for the probability density function of the FET from a strip. The schemes of two simulation algorithms are provided and performed. Some numerical and simulation results are given and discussed.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Mathematics
Publisher:	AIMS Press
ISSN:	1547-1063
Date of First Compliant Deposit:	2 June 2025
Date of Acceptance:	24 February 2025
Last Modified:	02 Jun 2025 14:15
URI:	https://orca.cardiff.ac.uk/id/eprint/178664

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