Emerging patents versus brain eating amoebae, Naegleria fowleri

Siddiqui, Ruqaiyyah, Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 and Khan, Naveed Ahmed 2025. Emerging patents versus brain eating amoebae, Naegleria fowleri. Pharmaceutical Patent Analyst 10.1080/20468954.2025.2459584

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Abstract

Primary Amoebic Meningoencephalitis (PAM) is a severe and often fatal infection caused by the free-living amoebae Naegleria fowleri. This condition typically results from exposure to contaminated warm freshwater/inadequately treated recreational water/or ablution/nasal irrigation with contaminated water. The management of PAM is hindered by the absence of effective treatment coupled with challenges in early diagnosis. This review explores emerging patents that could be utilized for the treatment, diagnosis of PAM, as well as water treatment. Recent patents from the past five years, along with research and innovations are reviewed and categorized into therapeutic agents, water treatment technologies, and diagnostic methods. It is hoped that collaboration and awareness between pharmaceutical companies, water industries, and academic institutions is essential for advancing effective strategies against this severe central nervous system pathogen.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Taylor and Francis Group
ISSN:	2046-8954
Date of First Compliant Deposit:	30 June 2025
Date of Acceptance:	21 January 2025
Last Modified:	03 Feb 2026 02:45
URI:	https://orca.cardiff.ac.uk/id/eprint/178797

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