Exploring the bactericidal efficacy of a new potassium monopersulphate-based disinfectant

Barbosa, P. P., Leme, D. M., Motta, N. G., Magalhães, W. L. E., Proenca-Modena, J. L. and Maillard, J-Y ORCID: https://orcid.org/0000-0002-8617-9288 2025. Exploring the bactericidal efficacy of a new potassium monopersulphate-based disinfectant. Journal of Hospital Infection 10.1016/j.jhin.2025.04.033 Item availability restricted.

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Abstract

Staphylococcus aureus and Klebsiella pneumoniae are common pathogens responsible for hospital-acquired infections. Both species can survive on surfaces following desiccation and form dry surface biofilms (DSB), which complicates the disinfection process. To evaluate the efficacy of an innovative potassium monopersulphate-based nanotechnology formulation (MPS) against both planktonic and sessile S. aureus and K. pneumoniae. The bactericidal efficacy of MPS was tested in comparison with sodium hypochlorite (NaOCl) and didecyldimethylammonium chloride (DDAC), which served as controls. The assessment was performed against planktonic bacteria, hydrated biofilm, and dry surface biofilm (DSB) using standard suspension and carrier tests. Scanning electron microscopy (SEM) was employed to identify any gross structural damage. MPS (2% w/v) achieved a ≥4 log reduction in K. pneumoniae with a short contact time, regardless of the test protocol. S. aureus proved more resilient, but the introduction of wiping reduced the contact time needed to achieve a 4 log reduction from 15 to 5 minutes. SEM analysis revealed gross structural damage in both species following MPS treatment. The other disinfectants tested were also bactericidal, achieving ≥4 log reduction within 1-5 minutes, with the exception of DDAC against hydrated biofilms. The potassium monopersulphate-based formulation was found to be an effective bactericide, including against dry surface biofilms (DSB). Its efficacy compares favourably with other biocides commonly used in healthcare settings, and its biodegradability makes it a promising candidate for further development. However, optimisation of the mechanical removal process will be essential to enhance MPS efficacy in practical applications. [Abstract copyright: Copyright © 2025. Published by Elsevier Ltd.]

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Pharmacy
Publisher:	Elsevier
ISSN:	0195-6701
Date of First Compliant Deposit:	9 June 2025
Date of Acceptance:	23 April 2025
Last Modified:	09 Jun 2025 14:00
URI:	https://orca.cardiff.ac.uk/id/eprint/178921

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