Treatment options for managing anovulation in women with PCOS: an extensive literature review of evidence-based recommendations for future directions

Mahoney, Alessia and D’Angelo, Arianna 2025. Treatment options for managing anovulation in women with PCOS: an extensive literature review of evidence-based recommendations for future directions. Life 15 (6) , 863. 10.3390/life15060863

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Abstract

Polycystic ovary syndrome (PCOS) is the expression of a complex alteration of the reproductive system. It is characterised by the increase in androgens, causing symptoms such as hirsutism, as well as infertility in many. This paper reviews whether Clomiphene Citrate, Letrozole and Inositol function better as monotherapy or combined therapy for anovulatory infertile PCOS patients. Ovulation and pregnancy rate were used as primary outcomes. PubMed and Scopus were the search engines of choice. Papers were excluded if patients were undertaking other fertility interventions, overlapping populations and non-RCT papers. It was found that co-prescribing Letrozole or Clomiphene Citrate alongside Metformin should be considered, Inositol should be examined as an alternative insulin sensitiser to Metformin and studies should be undertaken to identify the ideal dose and duration of Inositol therapy. Further large, well-designed, multi-centre studies should be conducted to solidify the claims of this review.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Start Date: 2025-05-27
Publisher:	MDPI
Date of First Compliant Deposit:	13 June 2025
Date of Acceptance:	21 May 2025
Last Modified:	13 Jun 2025 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/179072

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