Target selection signals causally influence human perceptual decision-making

Pearce, Daniel J., Loughnane, Gerard M., Chong, Trevor T.-J., Demeyere, Nele, Mattingley, Jason B., Moore, Margaret J., New, Peter W., O'Connell, Redmond G., O'Neill, Megan H., Rangelov, Dragan, Stolwyk, Renerus J., Webb, Sam S., Zhou, Shou-Han, Brosnan, Méadhbh B. and Bellgrove, Mark A. 2025. Target selection signals causally influence human perceptual decision-making. The Journal of Neuroscience 45 (24) , e2048242025. 10.1523/JNEUROSCI.2048-24.2025

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Abstract

The ability to form decisions is a foundational cognitive function which is impaired across many psychiatric and neurological conditions. Understanding the neural processes underpinning clinical deficits may provide insights into the fundamental mechanisms of decision-making. The N2c has been identified as an EEG signal indexing the efficiency of early target selection, which subsequently influences the timing of perceptual reports through modulating neural evidence accumulation rates. Evidence for the contribution of the N2c to human decision-making however has thus far come from correlational research in neurologically healthy individuals. Here, we capitalized on the superior temporal resolution of EEG to show that unilateral brain lesions in male and female humans were associated with specific deficits in both the timing and strength of the N2c in the damaged hemisphere, with corresponding deficits in the timing of perceptual reports contralaterally. The extent to which the N2c influenced clinical deficits in perceptual reporting speed depended on neural rates of evidence accumulation. This work provides causal evidence that the N2c indexes an early, hemisphere-specific process supporting human decision-making. This noninvasive EEG marker could be used to monitor novel approaches for remediating clinical deficits in perceptual decision-making across a range of brain disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Engineering
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of Acceptance:	24 April 2025
Last Modified:	24 Jun 2025 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/179084

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