Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention

Lemor, Alejandro, Shah, Tayyab, Thompson, Julia B., Protty, Majd B., Mamas, Mamas A., Kinnaird, Tim, Bharadwaj, Aditya S., Truesdell, Alexander G., Schonning, Michael J., Zhang, Yiran, Hussain, Yasin, Falah, Batla, Cohen, David J., Redfors, Björn, Baron, Suzanne J., Witzke, Christian F., Dixon, Simon R., Basir, Mir B., Lansky, Alexandra J. and O'Neill, William W. 2025. Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention. Cardiovascular Revascularization Medicine 10.1016/j.carrev.2025.05.031

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Abstract

Background High-risk percutaneous coronary intervention (HRPCI) procedures supported by percutaneous left ventricular assist devices (pLVAD) are increasingly common, but existing PCI risk scores were developed in patients across the risk spectrum, including few pLVAD-assisted patients. Objectives Assess the performance of existing PCI risk scores in patients receiving pLVAD-assisted HRPCI and create a novel risk score specific to this group. Methods Patients in the PROTECT III multicenter, observational (46 US centers) study undergoing pLVAD-assisted HRPCI were assessed. The National Cardiovascular Data Registry (NCDR) bedside risk score and the Complex High-Risk Indicated PCI (CHIP-PCI) risk score were calculated for each patient, and their accuracy in predicting in-hospital events was assessed. A novel risk score for in-hospital mortality was created using pre-procedural variables which were significant in univariable and multivariable regressions. Results Among 1237 patients, the NCDR bedside risk score showed modest discrimination (C-index 0.71) but poor goodness of fit (R2 = 0.30). The CHIP-PCI score had poor discrimination (C-index 0.61) and reasonable goodness of fit (R2 = 0.62). Five independent predictors of in-hospital mortality were identified: age >80 years, eGFR <30, left main disease, acute myocardial infarction, and left ventricular ejection fraction <30 %. These formed the “HRPCI” risk score (C-index 0.75), which correlated with 30-day mortality (5.4 % vs. 17.0 %, p<0.0001). Conclusions Existing PCI risk scores perform poorly in patients undergoing pLVAD-assisted HRPCI. A novel easily, calculable HRPCI risk score can assist in clinical decision making once validated.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Publisher:	Elsevier
ISSN:	1553-8389
Date of Acceptance:	29 May 2025
Last Modified:	01 Jul 2025 13:15
URI:	https://orca.cardiff.ac.uk/id/eprint/179405

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