PGF isoforms, PLGF-1 and PGF-2, in colorectal cancer and the prognostic significance

Escudero-Esparza, Astrid, Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Davies, Mansel Leigh and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2009. PGF isoforms, PLGF-1 and PGF-2, in colorectal cancer and the prognostic significance. Cancer Genomics and Proteomics 6 (4) , pp. 239-246.

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Abstract

Aim: This study examined the expression of PLGF-1 and PGF-2 in human colorectal cancer and how changes in expression may be linked to prognosis of the disease. Materials and Methods: Expression of PLGF transcripts in primary colorectal tumours (n=94) and background tissue (n=80) were analysed by Q-PCR. Immunohistochemistry was carried out on a number of matched background and tumour sections. Results: There was a progressive increase in Dukes A to C (430±134 versus 674±2680) and with TNM 1 to 3 as compared to background tissues (479±152 versus 777±327 p=0.032). Interestingly, there was an increase in PLGF-1 expression in patients with poor outcome compared with patients remaining disease-free. PGF-2 expression was significantly elevated in tumours compared to normal (4558±240 versus 859±67.3 p<0.0001). Moreover, expression was increased in patients with poor prognosis compared to those remaining disease free (4585±285 versus 3909±446). Conclusion: There is increased expression of the PLGF isoforms in human colorectal cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Colorectal cancer; immunohistochemistry; placenta growth factor; prognosis; real-time quantitative polymerase chain reaction; vascular endothelial growth factor
Publisher:	International Institute of Anticancer Research
ISSN:	1109-6535
Last Modified:	18 Oct 2022 14:33
URI:	https://orca.cardiff.ac.uk/id/eprint/17949

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