Decorin treatment of spinal cord injury.

Esmaeili, Maryam, Berry, Martin, Logan, Ann and Ahmed, Zubair 2014. Decorin treatment of spinal cord injury. Neural Regeneration Research 9 (18) , pp. 1653-1656. 10.4103/1673-5374.141797

PDF - Published Version Available under License Creative Commons Attribution. Download (197kB)

Abstract

The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Optometry and Vision Sciences
Publisher:	Medknow Publications
ISSN:	1673-5374
Related URLs:	Publisher
Date of First Compliant Deposit:	4 July 2025
Date of Acceptance:	18 August 2014
Last Modified:	04 Jul 2025 13:30
URI:	https://orca.cardiff.ac.uk/id/eprint/179500

Actions (repository staff only)

Edit Item