The Baeyer-Villiger oxidation of cubyl ketones: a synthetic route to functionalized cubanols

Hind, Jasmine, Fallis, Ian. A. ORCID: https://orcid.org/0000-0001-7361-0182, Platts, James. A. ORCID: https://orcid.org/0000-0002-1008-6595 and Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611 2025. The Baeyer-Villiger oxidation of cubyl ketones: a synthetic route to functionalized cubanols. Organic Letters 10.1021/acs.orglett.5c02760

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Abstract

The synthesis of functionalized cubanols has been developed via a 2-step protocol comprising of a Baeyer–Villiger oxidation of cubyl ketones, followed by acid hydrolysis. As part of this study, we determine the relative migratory aptitude of cubyl groups in the Baeyer–Villiger oxidation and rationalize these experimental findings with computational studies.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Chemistry
Publisher:	American Chemical Society
ISSN:	1523-7060
Date of First Compliant Deposit:	12 August 2025
Date of Acceptance:	7 August 2025
Last Modified:	12 Aug 2025 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/180326

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