Clinical trials evaluating desensitising agents. Some design and analysis issues

Newcombe, Robert G. ORCID: https://orcid.org/0000-0003-4400-8867, Seong, Joon and West, Nicola X. 2023. Clinical trials evaluating desensitising agents. Some design and analysis issues. Journal of dentistry 128 , 104380. 10.1016/j.jdent.2022.104380

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Abstract

Introduction: The purpose of this short communication is to draw attention to an efficient design for trials to evaluate desensitising agents, and an appropriate statistical analysis. Methods: Two recent sensitivity trials conducted by the Bristol Dental School Clinical Trials Group are reviewed. Results: The methodology used was effective to establish efficacy of the products evaluated. Conclusions: This methodology is recommended for wider use. Clinical significance: Effective clinical trial methodology enables establishment of efficacy of desensitising products leading to patient benefit.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	0300-5712
Date of First Compliant Deposit:	2 September 2025
Date of Acceptance:	23 November 2022
Last Modified:	02 Sep 2025 14:24
URI:	https://orca.cardiff.ac.uk/id/eprint/180836

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