Randomized clinical trial to determine if changes in dentine tubule occlusion visualized by SEM of replica impressions correlate with pain scores

Seong, J., Davies, M., MacDonald, E. L., Claydon, N. C. A. and West, N. X. 2018. Randomized clinical trial to determine if changes in dentine tubule occlusion visualized by SEM of replica impressions correlate with pain scores. American Journal of Dentistry 31 , pp. 189-194.

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Abstract

Purpose: To quantify dentine tubule occlusion and correlate this with pain reduction in vivo. Methods: This was a single-center, randomized two treatment, examiner-blind, parallel study. 20 participants with confirmed dentine hypersensitivity (DH) were evaluated by Schiff Air Blast, VAS Air Blast and replica impression of the tooth surface to visualize tubule occlusion at baseline and following 4 week twice daily use of either an occluding toothpaste (8\% strontium acetate, 1040 ppm fluoride) or a non-occluding toothpaste (1450ppm fluoride). Results: Both treatments increased tubule occlusion significantly from baseline to 4 weeks (p = 0.01) with significant decreases in pain score only seen with the occluding toothpaste (Schiff, p = 0.01; VAS, p = 0.01). Schiff pain score after 4 weeks was markedly reduced following treatment with the occluding toothpaste as compared to the non-occluding toothpaste, (p = 0.05) with no significant differences between the pastes for occlusion score or patient reported VAS, although the scores favored the occluding toothpaste. Clinical Significance: Occlusion scores as obtained by replica impression techniques with SEM imaging correlate significantly with DH pain scores confirming proof of concept. With further refinement, this technique could be used to accurately quantify tubule occlusion in vivo and the associated pain reduction achieved by occluding toothpastes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry
Publisher:	Mosher and Linder Inc
ISSN:	0894-8275
Last Modified:	09 Sep 2025 13:15
URI:	https://orca.cardiff.ac.uk/id/eprint/180905

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