Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice

West, Nicola X., He, Tao, Hellin, Nikki, Claydon, Nicholas, Seong, Joon, Macdonald, Emma, Farrell, Svetlana, Eusebio, Rachelle and Wilberg, Aneta 2018. Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice. International Journal of Dental Hygiene 17 (3) , pp. 261-267. 10.1111/idh.12379

PDF - Published Version Available under License Creative Commons Attribution. Download (802kB)

Abstract

Objectives: To assess the protective effects of a 0.454\% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10-day in situ model. Methods: This was a double-blind, randomized, 2-treatment, 4-period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454\% stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24\% sodium fluoride and 0.3\% triclosan (Colgate-Palmolive). Each study period took place over 10 days. Participants wore an intra-oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10-minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. Results: Thirty-six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5\% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. Conclusion: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry
Publisher:	Wiley
ISSN:	1601-5029
Date of First Compliant Deposit:	8 September 2025
Date of Acceptance:	29 November 2018
Last Modified:	08 Sep 2025 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/180911

Actions (repository staff only)

Edit Item