GLP‐1 agonist‐associated presentations to unscheduled care: An opportunistic pilot study

Thomas, Oliver and Coulson, James Michael 2025. GLP‐1 agonist‐associated presentations to unscheduled care: An opportunistic pilot study. British Journal of Clinical Pharmacology 10.1002/bcp.70335

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Abstract

The impact of GLP‐1 or GIP/GLP‐1 receptor agonist use on unscheduled care is not well‐described. We conducted a prospective, observational study using opportunistic screening by clinicians as a first step to understanding the effect of GLP‐1 or GIP/GLP‐1 agonists on Emergency Department presentations and to guide future studies. Data were collected from April to August 2025 at a single centre for any nontrauma adult patient who self‐reported GLP‐1 or GIP/GLP‐1 agonist exposure. Fifty‐six cases were identified, 51 reported tirzepatide use, three subcutaneous semaglutide, one oral semaglutide and one dulaglutide. In 79% of cases (CI95% 66% to 88%), the presenting features were due to GLP‐1 or agonist use. Presentations were greatest in the lowest and highest deprivation quintiles and a significant number had coexisting depression. There is a need for formal observational studies to assess the impact of GLP‐1 or GIP/GLP‐1 agonists on unscheduled care and explore these tentative associations.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley
ISSN:	0306-5251
Date of First Compliant Deposit:	13 November 2025
Date of Acceptance:	15 October 2025
Last Modified:	13 Nov 2025 11:45
URI:	https://orca.cardiff.ac.uk/id/eprint/182393

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