Alsulaimany, Marwa, Simons, Claire  ORCID: https://orcid.org/0000-0002-9487-1100 and Abdallah, Nehad A.
2025.
Exploring a new role of cyclic and acyclic ionophores in the potentiometric recognition of organic drug molecules beyond metal ions: Case study with ephedrine hydrochloride.
Journal of the Indian Chemical Society
102
(12)
, 102269.
10.1016/j.jics.2025.102269
|
Abstract
In electrochemical sensing platforms, monensin sodium and nonactin ionophores have been extensively used for the selective recognition of metal cations. The objective of this research is to study and compare their potential for the selective potentiometric detection of ephedrine hydrochloride, a small organic cation. Ephedrine hydrochloride was chosen because of its small molecular size and flexibility, which facilitate its incorporation and binding with ionophores. To measure the concentration of ephedrine hydrochloride, two carbon paste electrodes were designed, where monensin sodium (carbon paste electrode 1) and nonactin (carbon paste electrode 2) served as recognition elements. A combination of CuO and multiwalled carbon nanotubes was employed as an ion-to-electron transducer. The electrodes' selectivity, sensitivity, and response toward ephedrine hydrochloride were evaluated according to IUPAC guidelines. The studied electrodes showed linearity over the concentration ranges of 1 × 10−3 M to 1 × 10−5 M and × 10−2 M to 1 × 10−7 M with LOD values of 5 × 10−6 M and 9 × 10−8 M, for electrodes 1 and 2, respectively. They exhibited high stability for approximately 73 and 95 days, respectively, with no surface renewal action. Both electrodes were used to measure the concentrations of ephedrine hydrochloride in spiked human plasma, pure form, and in different pharmaceutical dose forms.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Pharmacy |
| Publisher: | Indian Chem Soc |
| ISSN: | 0019-4522 |
| Date of Acceptance: | 10 November 2025 |
| Last Modified: | 25 Nov 2025 10:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/182618 |
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