Duijts, Liesbeth, Um Bergström, Petra, Kotecha, Sarah, Kotecha, Sailesh  ORCID: https://orcid.org/0000-0003-3535-7627 and Pijnenburg, Mariëlle W.
2025.
Management of prematurity-associated lung disease from infancy through to adulthood.
The Lancet Respiratory Medicine
10.1016/S2213-2600(25)00369-8
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Abstract
Preterm birth has lifelong pulmonary consequences, with many individuals developing prematurity-associated lung disease (PLD). This third paper in the prematurity-associated lung disease Series summarises current evidence for treatment and monitoring of PLD and its phenotypes. Preventive strategies, including maternal and infant vaccination to reduce early life viral exposures, are emerging as key interventions. Pharmacological approaches, such as inhaled corticosteroids, alone or combined with long-acting bronchodilators, show potential benefits in childhood, although there is currently little evidence on phenotype-specific responses. Management should also address extrapulmonary traits, including central airway abnormalities, cardiovascular sequelae, gastro-oesophageal reflux, impaired growth, neurodevelopmental disabilities, reduced physical exercise capacity, and environmental exposures. We discuss monitoring tools for early identification and longitudinal assessment of PLD, evaluation of treatment response, and recommendations for structured follow-up from infancy into adulthood, suitable for both general and specialist respiratory clinicians. Finally, opportunities for repurposing existing drugs and developing new therapies for PLD in children and adults are highlighted.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | In Press |
| Schools: | Schools > Medicine Research Institutes & Centres > Centre for Trials Research (CNTRR) |
| Additional Information: | RRS applied AB 02/12/2025 |
| Publisher: | Elsevier |
| ISSN: | 2213-2600 |
| Funders: | MRC |
| Date of First Compliant Deposit: | 2 December 2025 |
| Date of Acceptance: | 9 October 2025 |
| Last Modified: | 02 Dec 2025 17:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/182764 |
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