Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Principles of the Ca2+ homeostatic/signalling system

Verkhratsky, Alexei and Petersen, Ole Holger 2010. Principles of the Ca2+ homeostatic/signalling system. In: Verkhratsky, Alexei and Petersen, Ole Holger eds. Calcium Measurement Methods, Neuromethods, vol. 43. New York: Humana Press, pp. 1-11. (10.1007/978-1-60761-476-0_1)

Full text not available from this repository.


Calcium ions are the most ubiquitous and pluripotent signalling molecules, which regulate a wide array of physiological and pathological reactions. The specific system, controlling cellular Ca2+ homeostasis appeared very early in the evolution, being initially survival system preventing Ca2+-mediated cell damage. Subsequently, the steep Ca2+ gradients maintained by Ca2+ homeostatic molecular cascades became the basis for Ca2+ signalling. This signalling system utilises Ca2+ channels and transporters localised in plasmalemma and intracellular membranes to create highly organised and compartmentalised cytosolic Ca2+ fluctuations occurring within the spatial and temporal domains. Changes in cytosolic Ca2+ concentrations regulate a multitude of Ca2+-dependent proteins, which serve as “Ca2+ sensors” and thus the effectors of Ca2+ signalling system.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > Q Science (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Calcium ; Ca2+ homeostasis ; Ca2+ signalling ; Neurones ; Glia ; Nervous system
Additional Information: pbk ISBN: 9781617796777
Publisher: Humana Press
ISBN: 9781607614753
Related URLs:
Last Modified: 04 Jun 2017 03:13

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item