Magnetization transfer imaging in multiple sclerosis

Mancini, Matteo and Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456 2024. Magnetization transfer imaging in multiple sclerosis. Jakimovski, Dejan and Zivadinov, Robert, eds. Handbook of Imaging in Multiple Sclerosis, Elsevier, pp. 191-205. (10.1016/B978-0-323-95739-7.00003-4)

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Abstract

Magnetization transfer (MT) imaging is a magnetic resonance imaging (MRI) technique sensitized to the exchange of magnetization between macromolecular tissue content and water. As in the white matter this process is dominated by myelin, it has been used as a proxy for myelin in the human brain. Quantification of these effects can be obtained through the magnetization transfer ratio, or through analytical modeling of the exchange process (quantitative magnetization transfer). The sensitivity of MT-derived quantities to myelin is supported by several animal and postmortem studies. In multiple sclerosis, MT parameters have shown differences between lesions and normal appearing white matter and temporal changes associated with lesion evolution. Correlations with clinical scores are mild to moderate. Protocols to quantify MT effects in the spinal cord and optic nerve have also been proposed.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISBN:	9780323957397
Last Modified:	03 Dec 2025 11:45
URI:	https://orca.cardiff.ac.uk/id/eprint/182865

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