Tractography validation Part 2: The use of anatomical model systems and measures for validation

Dyrby, Tim B., Sarubbo, Silvio, Rheault, Francois, Fieremans, Els, Anderson, Adam W., Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Neher, Peter, Rockland, Kathleen S. and Schilling, Kurt G. 2025. Tractography validation Part 2: The use of anatomical model systems and measures for validation. Dell'acqua, F., Descoteaux, M. and Leemans, A., eds. Handbook of Diffusion MR Tractography, Elsevier, pp. 511-542. (10.1016/B978-0-12-818894-1.00020-3)

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Abstract

Tractography validation is the act of assessing and quantifying the relationship between anatomy and tractography. Validation enables the ability to assess the strengths and limitations of the fiber tractography process, and aims to ultimately understand, improve, and refine the process of fiber tractography. The focus of this chapter and the previous chapter is to give insight into different strategies, technologies, and models that can be used to validate tractography. The target reader group ranges broadly from the beginner level who need basic insights into practical experiences, tips, and tricks, to the advanced level for the state of art of cross-modality validation and reflections. In the previous chapter (part 1) of tractography validation, we describe the basis for the validation of tractography across the various anatomical length scales included in the processing pipeline. Then we follow one of two topics of validation strategies basically formed as cook-books containing detailed descriptions of validation methods from the brain network to the microstructure level. In this chapter (part 2), we cover the second topic including validation using anatomical model systems, i.e., (1) application in real tissue, (2) empirical validation (when we do not have a ground truth), and (3) measures for validation (how to quantify validation). The final third chapter (part 3) highlights what we have learned through validation studies, with a focus on how these were learned and their implications for tractography and gives perspective on the future challenges of tractography.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Schools > Psychology
Publisher:	Elsevier
ISBN:	9780128188941
Last Modified:	16 Dec 2025 15:30
URI:	https://orca.cardiff.ac.uk/id/eprint/183299

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