Methods and statistics for diffusion MRI tractometry

Chamberland, Maxime, St-Jean, Samuel, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Descoteaux, Maxime and Leemans, Alexander 2025. Methods and statistics for diffusion MRI tractometry. Dell'acqua, Flavio, Descoteaux, Maxime and Leemans, Alexander, eds. Handbook of Diffusion MR Tractography: Imaging Methods, Biophysical Models, Algorithms and Applications, Elsevier, pp. 439-450. (10.1016/B978-0-12-818894-1.00023-9)

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Abstract

Analyzing microstructural properties projected along white matter pathways derived from diffusion magnetic resonance imaging (MRI) has become increasingly popular in recent years. Along-streamline profiling based on diffusion MRI tractometry is a framework that maps summary measures of the diffusion data (e.g., fractional anisotropy) at multiple points along a given pathway, resulting in a so-called bundle-profile. In this chapter, we introduce the various steps involved in along-streamline profiling, covering concepts related to bundle segmentation, core streamline definition, and statistical analysis of bundle-profiles. Our aim is to provide a general overview of the tractometry framework and to encourage its application.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology
Publisher:	Elsevier
ISBN:	9780128188941
Last Modified:	17 Dec 2025 12:23
URI:	https://orca.cardiff.ac.uk/id/eprint/183314

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