Wood, Callum, Owen, Stephanie, Ebden, Sian, Anand, Bawani, Wardle, Mark, Hamandi, Khalid, Kreft, Karim L., Robertson, Neil P.  ORCID: https://orcid.org/0000-0002-5409-4909 and Tallantyre, Emma ORCID: https://orcid.org/0000-0002-3760-6634
2025.
47 Multiple sclerosis and seizures: clinical, diagnostic and therapeutic correlations [Abstract].
Journal of Neurology, Neurosurgery and Psychiatry
96
, A15.
10.1136/jnnp-2025-abn.47
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Abstract
Introduction Seizures occur more commonly in people with Multiple Sclerosis (pwMS) than in the general population. We characterize a population-based cohort of pwMS/CIS and seizure(s). Methods The South Wales MS registry was used to identify all people with MS/CIS and a history of seizure living in Cardiff and Vale between 2006-2023; the prevalent population was calculated on the 1st January 2020 for the catchment area. MR brain images nearest to time of first seizure were reviewed and compared to a matched cohort of pwMS without seizures. Results We identified 49 historical cases of co-existent MS/CIS and seizure(s). On 1st January 2020 we found that 2.4% (23/950) of the prevalent population of people with MS/CIS had experienced a seizure and 2.1% (20/950) had a diagnosis of epilepsy. Seizures occurred before other symptoms of MS in 15/49 and after MS in 34/49. One patient experienced seizure during MS relapse. Analysis of MR brain images suggests that PwMS and seizures have a higher number of T2 lesions and more marked brain atrophy. Conclusion This study suggests that approximately 2.4% of people with MS are expected to experience seizure(s). Seizures in MS are associated with higher overall brain disease burden
| Item Type: | Short Communication |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | BMJ Publishing Group |
| ISSN: | 0022-3050 |
| Last Modified: | 20 Jan 2026 16:15 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/184077 |
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