Finlayson, Marcia, Poli, Silvia, Bozzoli, Federico, Brichetto, Giampaolo, Bø, Lars, Busch, Isolde Martina, Dalgas, Ulrik, Evangelou, Nikos, Farrin, Amanda, Freeman, Jennifer, Jidborg, Helena, Kos, Daphne, Marck, Claudia H., Ontaneda, Daniel, Podda, Jessica, Rimondini, Michela, Swain, Polly, Tallantyre, Emma  ORCID: https://orcid.org/0000-0002-3760-6634, Taylor, Lauren A. and das Nair, Roshan
2025.
Designing well-being intervention trials for people with progressive multiple sclerosis: the importance of understanding usual care comparators [Editorial].
International Journal of MS Care
27
, T27-T31.
10.7224/1537-2073.2024-099
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Abstract
Well-being captures an individual’s capacity to lead a meaningful and engaged life. Interventions to address well-being go beyond managing symptoms or supporting daily activity performance. Designing trials to evaluate the effectiveness of such well-being interventions can be challenging. One such challenge is determining what the comparator or control arm should be. Several trials of complex interventions use usual care as a comparator, but this can be particularly challenging when planning trials across multiple countries and health care systems. Therefore, trial design decisions must be informed by a good understanding of what constitutes usual or routine well-being interventions across locations. Our international, multidisciplinary team’s efforts to develop this understanding across our 8 countries found that efforts to support the well-being of people with progressive multiple sclerosis vary widely. This variability emphasizes the importance of having a consistent way to collect data and report on the components of usual well-being care to inform trial design.
| Item Type: | Short Communication |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Additional Information: | Right Retention applied |
| Publisher: | Consortium of Multiple Sclerosis Centers |
| ISSN: | 1537-2073 |
| Date of First Compliant Deposit: | 3 February 2026 |
| Last Modified: | 03 Feb 2026 09:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/184359 |
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