Evidence for glycosaminoglycans as a major component of trail mucus from the terrestrial slug, Arion ater L.

Cottrell, J., Henderson, I., Pickett, J. ORCID: https://orcid.org/0000-0002-8386-3770 and Wright, D. 1993. Evidence for glycosaminoglycans as a major component of trail mucus from the terrestrial slug, Arion ater L. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology 104 (3) , pp. 455-468. 10.1016/0305-0491(93)90267-9

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Abstract

1. SDS-PAGE of trail mucus from seven species of terrestrial mollusc revealed few similarities in the pattern of protein or carbohydrate-containing bands. 2. The trail mucus of the black slug, Arion ater L. contained 1–2% solids (9% protein, 21% hexose, 31% uronic acid, 39% hexosamine, 1% sulphate and <1% sialic acid). 3. The major carbohydrate fraction (50–100 kDa) after borohydride reduction of A. ater mucus, was shown by PAGE and FAB-MS to consist of long chains of a repeating disaccharide, probably HexNAc-HexUA. The linkage sugar between carbohydrate and protein was a hexosamine, GlcN(Ac) or possibly GalN(Ac). 4. The carbohydrate fraction and whole A. ater mucus were susceptible to digestion with heparinase III, but not heparinase I, heparinase II, hyaluronidase or chondroitin sulphate ABC lyase, suggesting a structure similar to that of heparan sulphate.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Publisher:	Elsevier
ISSN:	1096-4959
Date of Acceptance:	16 October 1991
Last Modified:	06 Feb 2026 15:45
URI:	https://orca.cardiff.ac.uk/id/eprint/184492

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