Animal models of glaucoma

Tomarev, S. I. and Mead, Ben ORCID: https://orcid.org/0000-0001-5855-0097 2025. Animal models of glaucoma. D’Amore, Patricia A., ed. Encyclopedia of the Eye (2nd Ed.), Vol. 1. Elsevier, (10.1016/B978-0-443-13820-1.00102-X)

Full text not available from this repository.

Abstract

Glaucoma is a complex disease, the initiation and progression of which involves interactions between different parts of the eye and brain. It is difficult to perform experiments directed toward elucidating pathogenic molecular mechanisms and potential treatments for glaucoma in human subjects. While postmortem material can be used for biochemical analysis, several hours of degenerative processes will have occurred before the tissue is in the hands of the researcher. Experiments in cell culture, organ culture or organoids systems may only partially reproduce the complexity of the natural ocular environment. It is now well recognized that animal models are a necessary tool for understanding the underlying molecular mechanisms involved in glaucoma and for identifying new genetic components or molecular targets of the disease, including both causative and modifier genes. This article briefly describes available animal models of glaucoma with emphasis on the strengths and weaknesses of each commonly used or potentially promising model.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Optometry and Vision Sciences
Publisher:	Elsevier
ISBN:	9780443138393
Last Modified:	10 Feb 2026 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/184567

Actions (repository staff only)

Edit Item