Confirmation of unidimensionality of the Dermatology Life Quality Index (DLQI) using a multinational 3,408 patient dataset

Johns, Jeffrey, Salek, Sam, Ali, Faraz, Dalgard, Florence, Kupfer, Jörg and Finlay, Andrew Y. ORCID: https://orcid.org/0000-0003-2143-1646 2026. Confirmation of unidimensionality of the Dermatology Life Quality Index (DLQI) using a multinational 3,408 patient dataset. Journal of Patient-Reported Outcomes 10.1186/s41687-026-01025-0

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Abstract

BACKGROUND: The Dermatology Life Quality Index (DLQI) was designed to be a simple, practical questionnaire for routine clinical use and is the most widely used tool to measure the burden of skin diseases and assess effectiveness of interventions based on patients' perspective. The aim of this study was to further validate the DLQI using a multinational European study dataset. METHODS: Data from a cross-sectional study conducted in 13 European countries were analysed. In each dermatology clinic, 250 consecutive adult out-patients were recruited. A wide range of classical test theory and IRT tools were used to investigate unidimensionality and known-group properties. RESULTS: From 3,635 patients, 3408 completed the DLQI with no missing data. 55.8% of patients were female, mean age 46.6 years (SD=17.82). The commonest conditions were psoriasis (17.4%), non-melanoma skin cancer (10.8%), infection of the skin (6.7%), hand eczema (6.2%) and acne (6.2%). Using DLQI score banding, the patients’ disease had no effect (n=962, 28.2%), small (912, 26.8%), moderate (674, 19.8%), very large (691, 20.3%) or extremely large effect (169, 5.0%) on their quality of life. Psychometric analyses employing eigenvalues, scree plots, item-response theory (IRT) and very simple structure indicated unidimensionality. Confirmatory factor analysis fits for a 1-factor solution were very good and a 1-factor model was optimum. IRT indicated good fit statistics, no misfitting items (infit and outfit), and no local dependencies (LG2 and Q3). Cronbach’s alpha was 0.90. Cohen’s-d effect sizes for DLQI scores between different EQ-5D item levels were moderate (>0.5) or large (>0.8), and large between different disease severity levels. Moderate correlation was found between EQ-5D VAS scale and DLQI score (r2 =-0.409, p<0.001). Known group analysis of DLQI score by severity was significant between groups (p<0.001). CONCLUSION: Analysis showed good psychometric properties confirming a 1-factor unidimensional model.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	SpringerOpen
Date of First Compliant Deposit:	16 February 2026
Date of Acceptance:	12 February 2026
Last Modified:	03 Mar 2026 14:30
URI:	https://orca.cardiff.ac.uk/id/eprint/184876

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