PACE-NODES: A phase III randomised trial of 5 fraction prostate stereotactic body radiotherapy (SBRT) versus 5 fraction prostate and pelvic nodal SBRT

Pathmanathan, Angela, Jain, Suneil, Staffurth, John ORCID: https://orcid.org/0000-0002-7834-3172, Brown, Stephanie, Burnett, Stephanie, Cafferty, Fay H., Choudhury, Ananya, Dewan, Monisha, Hoskin, Peter, McBride, Ken, McGarry, Conor K., Miles, Elizabeth, Murray, Julia, Murthy, Vedang, Naismith, Olivia, Song, Yee Pei, Syndikus, Isabel, Tree, Alison, Ward, Tim, Hall, Emma and van As, Nicholas 2026. PACE-NODES: A phase III randomised trial of 5 fraction prostate stereotactic body radiotherapy (SBRT) versus 5 fraction prostate and pelvic nodal SBRT. Clinical and Translational Radiation Oncology 58 , 101126. 10.1016/j.ctro.2026.101126

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Abstract

PACE-NODES is a phase III randomised controlled trial for patients with high risk localised prostate cancer, planned for radical radiotherapy with at least 12 months of androgen deprivation therapy, and suitable for stereotactic body radiotherapy (SBRT). Patients are randomised to receive either prostate SBRT (control) or prostate and pelvic nodal SBRT. In both arms, treatment is given in 5 fractions delivered on alternate days over 2 weeks. The aim of the trial is to determine whether prostate and pelvic nodal SBRT can improve outcomes for this patient group compared to prostate SBRT.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	2405-6308
Date of First Compliant Deposit:	23 February 2026
Date of Acceptance:	10 February 2026
Last Modified:	23 Feb 2026 13:02
URI:	https://orca.cardiff.ac.uk/id/eprint/185108

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