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Taming the Achilles’ heel: A chemical and structural design to address off-target effects in siRNA therapeutics

Parvathaneni, Rohith Pavan, Krishnan, Nithiyanandan, Hempel, Nikolai, Oommen, Oommen P. ORCID: https://orcid.org/0000-0003-2768-0133 and Varghese, Oommen P. 2026. Taming the Achilles’ heel: A chemical and structural design to address off-target effects in siRNA therapeutics. JACS Au 6 (2) , 795–800. 10.1021/jacsau.5c01765

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License URL: https://creativecommons.org/licenses/by/4.0/
License Start date: 9 February 2026
Item Type: Article
Date Type: Publication
Status: Published
Schools: Schools > Pharmacy
Additional Information: License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Start Date: 2026-02-09
Publisher: American Chemical Society
ISSN: 2691-3704
Date of First Compliant Deposit: 24 February 2026
Date of Acceptance: 3 February 2026
Last Modified: 24 Feb 2026 12:16
URI: https://orca.cardiff.ac.uk/id/eprint/185163

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