Multimodal pharmacological potential of newly synthesized organotin(IV) derivatives of 2,4-dichlorophenyl acetic acid

Rahim, Shahnaz, Khan, Ishaq N., Sadiq, Abdul, Saeed, Aiman, Fatima, Nighat, Kubicki, Maciej, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897, Muhammad, Niaz, Khan, Momin, Noor, Awal and Qayyum, Sadaf 2026. Multimodal pharmacological potential of newly synthesized organotin(IV) derivatives of 2,4-dichlorophenyl acetic acid. Journal of Chemical Sciences 138 , 12. 10.1007/s12039-025-02465-9

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Abstract

The pharmacological potential of six newly synthesized organotin(IV) carboxylates is reported. For the synthesis of complexes, R3SnCl/R2SnCl2 were reacted with sodium carboxylate salt NaL in dry chloroform {R = n-C4H9 (1, 4), CH3 (2, 5), C6H5 (3, 6) and L = 2,4-dichlorophenylacetate}. Microanalysis has validated the expected elemental composition of the complexes. FT-IR spectra suggested chelating/bridging bidentate coordination of the ligand in the complexes. A distorted trigonal-bipyramidal geometry around the Sn-atom was confirmed by single-crystal analysis in complex 1. The 1H and 13C NMR spectra have shown signals in the expected regions. In vitro studies have shown excellent biological potential of the complexes 1–6 than the ligand acid HL, with few exceptions. Among complexes, 1, 3 and 4 have shown promising anticancer potential against the U-87 cell line. Complex 5 was the most efficient COX-2, AChE and BChE inhibitor. Similarly, 1 has shown relatively lower IC50 values against α-glucosidase and α-amylase. All complexes, except 1, were more active scavengers of DPPH as compared to ABTS radicals. The antileishmanial potential of 1 was higher than the standard, Amphotericin B. Complex 1 has also shown better activity against P. aeruginosa and C. albicans as compared to the standard.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Publisher:	Indian Academy of Sciences
ISSN:	0974-3626
Date of Acceptance:	12 August 2025
Last Modified:	02 Mar 2026 13:08
URI:	https://orca.cardiff.ac.uk/id/eprint/185375

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