Targeting neutrophil function as therapy for hidradenitis suppurativa

Meldrum, Eric and Ingram, John R. ORCID: https://orcid.org/0000-0002-5257-1142 2026. Targeting neutrophil function as therapy for hidradenitis suppurativa. International Journal of Molecular Sciences 27 (4) , 2076. 10.3390/ijms27042076

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Abstract

Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterized by painful nodules, abscesses, and epithelialized tunnels, predominantly affecting flexural regions. With a global prevalence of approximately 1%, HS has a significant negative impact on quality of life. Multi-omics and histopathology studies have revealed a complex interplay between innate and adaptive immunity in HS, with neutrophils emerging as important drivers of inflammation. While therapies targeting TNF-α and IL-17 isoforms offer a degree of benefit, significant unmet need remains. Neutrophil signatures in HS lesions and the circulation underscore the rationale for selective modulation of neutrophil function. Strategies advancing through clinical trials include inhibition of chemokine-mediated trafficking, neutrophil serine protease inactivation and suppression of neutrophil extracellular traps (NETs), which amplify inflammatory and autoimmune responses. These emerging therapies mark a significant shift toward targeted neutrophil modulation, offering new opportunities to improve outcomes for patients with HS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	MDPI
ISSN:	1661-6596
Date of First Compliant Deposit:	3 March 2026
Date of Acceptance:	20 February 2026
Last Modified:	03 Mar 2026 12:31
URI:	https://orca.cardiff.ac.uk/id/eprint/185421

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