Highly selective and practical hydrogenation of functionalized (hetero)arenes

Qu, Ruiyang, Jena, Soumyashree, Xiao, Lifeng, Yang, Hui, Cai, Rongsheng, Bartling, Stephan, Atia, Hanan, Jackstell, Ralf, Franke, Robert, Junge, Kathrin, Jiao, Haijun, Hutchings, Graham J. ORCID: https://orcid.org/0000-0001-8885-1560 and Beller, Matthias 2026. Highly selective and practical hydrogenation of functionalized (hetero)arenes. Nature Communications 17 (1) , 2015. 10.1038/s41467-026-68537-7

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Abstract

Arenes, and particularly heteroarenes are integral structural components of a variety of chemicals and represent a privileged class of bioactive compounds found in pharmaceuticals, agrochemicals and vitamins. Diastereoselective hydrogenation of multi-substituted (hetero)arenes offers an efficient and industrially relevant approach to convert these compounds into valuable, diversified 3D building blocks for applications for example in drug innovation. We show that a rationally designed Pt catalyst permits the general diastereoselective hydrogenation of a broad range of multi-substituted and functionalized arenes and heteroarenes using mild conditions. The corresponding cyclic products are obtained with very high diastereoselectivity (d.r. value up to 99/1). The practical applicability of this catalysis is illustrated by the straightforward preparation of a novel plasticizer on kg-scale under solvent-free conditions.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by-nc-nd/4.0/, Type: open-access
Publisher:	Nature Research
Date of First Compliant Deposit:	3 March 2026
Date of Acceptance:	9 January 2026
Last Modified:	03 Mar 2026 14:45
URI:	https://orca.cardiff.ac.uk/id/eprint/185436

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