Delphi consensus guidelines for the use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy for the diagnosis of dementia and mild cognitive impairment with Lewy bodies

Donaghy, Paul C., Greenfinch, Gemma, Petrides, George, Kane, Joseph, Verberne, Hein J., Taylor, John‐Paul, O'Brien, John T., Thomas, Alan J. and Bradley, Kevin M. ORCID: https://orcid.org/0000-0003-1911-3382 2026. Delphi consensus guidelines for the use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy for the diagnosis of dementia and mild cognitive impairment with Lewy bodies. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 18 , e70296. 10.1002/dad2.70296

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Abstract

INTRODUCTION The aim of this Delphi process was to develop consensus guidelines to support the effective use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy in the diagnosis of dementia with Lewy bodies and mild cognitive impairment with Lewy bodies. METHODS A Delphi consensus panel of 37 international experts independently indicated their agreement or disagreement with statements on indications for the use of these biomarkers and clinical situations in which each biomarker should and should not be used. Statements were accepted if they reached > 80% agreement. RESULTS Overall, 36/70 statements (51%) were accepted in Round 1, and 19/37 (51%) were accepted in Round 2. DISCUSSION The Delphi consensus process has developed freely available guidelines outlining clinical situations in which striatal dopaminergic imaging and cardiac MIBG scintigraphy may be useful and considerations for their use, including the effect of specific comorbidities and medications on each of the biomarkers.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Additional Information:	Kevin M. Bradley contributed to this paper as part of the DLB Indicative Image Biomarker Study Group
Publisher:	Wiley Open Access
ISSN:	2352-8729
Date of First Compliant Deposit:	16 March 2026
Date of Acceptance:	9 February 2026
Last Modified:	16 Mar 2026 11:01
URI:	https://orca.cardiff.ac.uk/id/eprint/185762

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