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ADAMTS proteases: key roles in atherosclerosis?

Salter, Rebecca C., Ashlin, Timothy G., Kwan, Alvin P. L. and Ramji, Dipak Purshottam ORCID: 2010. ADAMTS proteases: key roles in atherosclerosis? Journal of Molecular Medicine 88 (12) , pp. 1203-1211. 10.1007/s00109-010-0654-x

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The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases are secreted enzymes that regulate extracellular matrix turnover by degrading specific matrix components. Roles for the proteases in inflammation and atherosclerosis have been suggested by a number of recent studies, and the role of ADAMTS-4 and -5 in the breakdown of aggrecan and subsequent degradation of cartilage during osteoarthritis has also been established. The ability of the ADAMTS proteases to degrade versican, the primary proteoglycan in the vasculature, is thought to be central to any hypothesized role for the proteases in atherosclerosis. In this review, we introduce the structure and function of the ADAMTS family of proteases and review the literature that links them with inflammation and atherosclerosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: ADAMTS ; atherosclerosis ; inflammation ; Versican ; extracellular matrix
ISSN: 0946-2716
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Last Modified: 19 Oct 2022 08:40

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