Infraslow (<0.1Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and disease states

Hughes, Stuart Wynn, Lőrincz, Magor, Parri, H. Rheinhallt and Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752 2011. Infraslow (<0.1Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and disease states. Presented at: 26th International Summer School of Brain Research, Amsterdam, Netherlands, 29 June-2 July 2010. Published in: Van Someren, Eus J. W., Van Der Werf, Ysbrand D., Roelfsema, Pieter R., Mansvelder, Hulbert D. and Lopes Da Silva, Fernando H. eds. Slow Brain Oscillations of Sleep, Resting State and Vigilance: proceedings of the 26th International Summer School of Brain Research. Progress in brain research (193) Elsevier, pp. 145-162. 10.1016/B978-0-444-53839-0.00010-7

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Abstract

In the absence of external stimuli the mammalian brain continues to display a rich variety of spontaneous activity. Such activity is often highly stereotypical, invariably rhythmic and can occur with periodicities ranging from a few milliseconds to several minutes. Recently there has been a particular resurgence of interest in fluctuations in brain activity occurring at <0.1 Hz, commonly referred to as very slow or infra-slow oscillations (ISOs). Whilst this is primarily due to the emergence of functional magnetic resonance imaging (fMRI) as a technique which has revolutionised the study of human brain dynamics it is also a consequence of the application of full band electroencephalography (fbEEG). Despite these technical advances the precise mechanisms which lead to ISOs in the brain remain unclear. In a host of animal studies, one brain region that consistently shows oscillations at <0.1 Hz is the thalamus. Importantly, similar oscillations can also be observed in slices of isolated thalamic relay nuclei maintained in vitro. Here, we discuss the nature and mechanisms of these oscillations, paying particular attention to a potential role for astrocytes in their genesis. We also highlight the relationship between this activity and ongoing local network oscillations in the alpha (α) (~8-13 Hz) band, drawing clear parallels with observations made in vivo. Lastly, we consider the relevance of these thalamic ISOs to the pathological activity that occurs in certain types of epilepsy.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Neuroscience and Mental Health Research Institute (NMHRI) Biosciences
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	acetylcholine; metabotropic glutamate receptor; EEG; gap junctions; alpha rhythm; epilepsy; adenosine; astrocytes; GIRK channels
Publisher:	Elsevier
ISBN:	9780444538390
Funders:	Wellcome Trust grants 71436, 78403, 91882, 78311
Last Modified:	19 Oct 2022 08:55
URI:	https://orca.cardiff.ac.uk/id/eprint/19487

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