Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease

Trueman, Rebecca C., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177 2012. Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 261-275. 10.1016/j.brainresbull.2011.03.015

Full text not available from this repository.

Abstract

Huntington's disease is the result of an expanded CAG repeat in the gene that codes for the protein huntingtin and results in a progressive sequelae of motor, cognitive and psychiatric symptoms. The development of genetically modified rodent models of Huntington's disease has led to the need for sensitive behavioural phenotyping. Operant tests for rodents have been developed that can determine the functional deficits in these genetically modified models, from motor, cognitive and emotional domains. The current review discusses tests that employ operant equipment, an automated and highly flexible method for testing rodents. Different operant paradigms are examined in relation to their relevance to Huntington's disease symptomology, as well as summarising research to date on genetic models with these tests.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Huntington’s disease; Operant; Cognition; Transgenic; Knock-in
Publisher:	Elsevier
ISSN:	0361-9230
Last Modified:	11 Mar 2023 02:33
URI:	https://orca.cardiff.ac.uk/id/eprint/19499

Citation Data

Cited 9 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item