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Dietary fatty acids and arthritis

Hurst, S., Zainal, Z., Caterson, Bruce ORCID:, Hughes, Clare Elizabeth ORCID: and Harwood, John L. ORCID: 2010. Dietary fatty acids and arthritis. Prostaglandins Leukotrienes & Essential Fatty Acids 82 (4-6) , pp. 315-318. 10.1016/j.plefa.2010.02.008

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Musculoskeletal complaints are the second most frequent reason for medical treatments. Within these diseases rheumatoid arthritis (RA) and, especially, osteoarthritis (OA) are common. Although the causes of arthritis are multifactorial and not fully understood, clinical trials have generally shown benefit from dietary n-3 polyunsaturated fatty acids. This has usually been attributed to their anti-inflammatory properties. Recently we have used in vitro model systems to study the molecular mechanism(s) by which n-3 PUFAs may act to alleviate the symptoms of arthritis. These experiments showed that n-3 PUFAs reduce expression of cartilage-degrading proteinases, cyclooxygenase-2 and inflammatory cytokines. Eicosapentaenoic acid (EPA) was more effective than docosahexaenoic acid (DHA) or alpha-linolenic acid. The data provide a scientific rationale for the consumption of n-3 fatty acids as part of a healthy diet and perhaps in treating arthritis.

Item Type: Article
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Omega-3 polyunsaturated fatty acids; dietary lipids; osteoarthritis; rheumatoid arthritis; eicosapentaenoic acid; docosahexaenoic acid
Publisher: Elsevier
ISSN: 0952-3278
Last Modified: 19 Oct 2022 09:00

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