Lane, Jane  ORCID: https://orcid.org/0000-0002-1926-4909, Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111
2011.
HGF and rhoGTPases in cancer cell motility.
Current Signal Transduction Therapy
6
(2)
, pp. 173-179.
10.2174/157436211795660052
|
Abstract
Hepatocyte growth factor/scatter factor (HGF/SF) acts as a mitogen, motogen and morphogen as well as an important angiogenic factor. In cancer cells, HGF/SF acts mainly as an inducer of cell migration and invasion with multiple motility signals mediated by the HGF receptor, c-MET. An important component in this signalling chain is the Rho/ROCK pathway, with resultant changes in cytoskeletal arrangement leading to cell motility/migration. This article outlines knowledge of HGF/SF in relation to cancer cell motility from previous reviews and focuses on more recent studies on the effect of HGF/SF in relation to RhoC GTPase and ROCK in breast cancer cells.
| Item Type: | Article |
|---|---|
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Uncontrolled Keywords: | Cancer cell motility; Hepatocyte growth factor/scatter factor; Rho; ROCK; GTPase; c-Met; metastasis; actin cytoskeleton; EMT; ribozyme; amoeboid cell motility; Y27632; lamellipodia; cancer cell invasion; RhoC; stress fibres; motility signals; Ras; doxycycline; mitogen; breat cancer; MDA-MB-231; MCF-7; Rho/rac pathway |
| Publisher: | Bentham Science Publishers |
| ISSN: | 1574-3624 |
| Last Modified: | 19 Oct 2022 09:06 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/20027 |
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