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HGF and rhoGTPases in cancer cell motility

Lane, Jane ORCID:, Martin, Tracey Amanda ORCID: and Jiang, Wen Guo ORCID: 2011. HGF and rhoGTPases in cancer cell motility. Current Signal Transduction Therapy 6 (2) , pp. 173-179. 10.2174/157436211795660052

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Hepatocyte growth factor/scatter factor (HGF/SF) acts as a mitogen, motogen and morphogen as well as an important angiogenic factor. In cancer cells, HGF/SF acts mainly as an inducer of cell migration and invasion with multiple motility signals mediated by the HGF receptor, c-MET. An important component in this signalling chain is the Rho/ROCK pathway, with resultant changes in cytoskeletal arrangement leading to cell motility/migration. This article outlines knowledge of HGF/SF in relation to cancer cell motility from previous reviews and focuses on more recent studies on the effect of HGF/SF in relation to RhoC GTPase and ROCK in breast cancer cells.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Cancer cell motility; Hepatocyte growth factor/scatter factor; Rho; ROCK; GTPase; c-Met; metastasis; actin cytoskeleton; EMT; ribozyme; amoeboid cell motility; Y27632; lamellipodia; cancer cell invasion; RhoC; stress fibres; motility signals; Ras; doxycycline; mitogen; breat cancer; MDA-MB-231; MCF-7; Rho/rac pathway
Publisher: Bentham Science Publishers
ISSN: 1574-3624
Last Modified: 19 Oct 2022 09:06

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