Transcriptomic underpinning of toxicant-mediated physiological function alterations in three terrestrial invertebrate taxa: A review.

Brulle, Franck, Morgan, Andrew John, Cocquerelle, Claude and Vandenbulcke, Franck 2010. Transcriptomic underpinning of toxicant-mediated physiological function alterations in three terrestrial invertebrate taxa: A review. Environmental Pollution 158 (9) , pp. 2793-2808. 10.1016/j.envpol.2010.06.019

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Abstract

Diverse anthropogenic activities often lead to the accumulation of inorganic and organic residues in topsoils. Biota living in close contact with contaminated soils may experience stress at different levels of biological organisation throughout the continuum from the molecular-genetic to ecological and community levels. To date, the relationship between changes at the molecular (mRNA expression) and biochemical/physiological levels evoked by exposures to chemical compounds has been partially established in a limited number of terrestrial invertebrate species. Recently, the advent of a family of transcriptomic tools (e.g. Real-time PCR, Subtractive Suppressive Hybridization, Expressed Sequence Tag sequencing, pyro-sequencing technologies, Microarray chips), together with supporting informatic and statistical procedures, have permitted the robust analyses of global gene expression changes within an ecotoxicological context. This review focuses on how transcriptomics is enlightening our understanding of the molecular-genetic responses of three contrasting terrestrial macroinvertebrate taxa (nematodes, earthworms, and springtails) to inorganics, organics, and agrochemicals.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	Soil invertebrates; Soil pollution; Gene expression; Transcriptomic analysis; Biomarkers of exposure; Signature of perturbation
Publisher:	Elsevier
ISSN:	0269-7491
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/20619...
Last Modified:	24 Mar 2017 03:11
URI:	https://orca.cardiff.ac.uk/id/eprint/20033

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