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Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Green, Elaine Karen, Grozeva, Detelina ORCID:, Escott-Price, Valentina ORCID:, Hamshere, Marian Lindsay ORCID:, Jones, Ian Richard ORCID:, Jones, Lisa, Forty, Elizabeth, Caesar, Sian, Gordon-Smith, Katherine, Fraser, Christine, Russell, Elen, St Clair, David, Young, Allan H., Ferrier, Nicol, Farmer, Anne, McGuffin, Peter, Holmans, Peter Alan ORCID:, Owen, Michael John ORCID:, O'Donovan, Michael Conlon ORCID: and Craddock, Nicholas John ORCID: 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (7) , pp. 1347-1349. 10.1002/ajmg.b.31108

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We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Systems Immunity Research Institute (SIURI)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: bipolar disorder; schizoaffective disorder; GABAA receptor; genetics
Publisher: Wiley-Blackwell
ISSN: 1552-4841
Last Modified: 05 Apr 2024 06:20

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