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No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

Sims, Rebecca ORCID:, Dwyer, Sarah Lynne, Harold, Denise ORCID:, Gerrish, Amy, Hollingworth, Paul, Chapman, Jade Alice, Denning, Nicola, Abraham, Richard Alun, Ivanov, Dobril ORCID:, Pahwa, Jaspreet Singh, Escott-Price, Valentina ORCID:, Dowzell, Kimberley Frances, Thomas, Charlene, Stretton, Alexandra, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuiness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Jones, Lesley ORCID:, Holmans, Peter Alan ORCID:, O'Donovan, Michael Conlon ORCID:, Owen, Michael John ORCID: and Williams, Julie ORCID: 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7) , pp. 764-771. 10.1002/ajmg.b.31216

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We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Systems Immunity Research Institute (SIURI)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: alzheimer’s disease; runs of homozygosity; genome-wide association study
Publisher: Wiley-Blackwell
ISSN: 1552-4841
Last Modified: 04 Mar 2023 02:55

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