A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

Thorp-Greenwood, Flora Lottie, Fernández-Moreira, Vanesa, Millet, Coralie Ode, Williams, Catrin Ffion ORCID: https://orcid.org/0000-0001-8619-2581, Cable, Joanne ORCID: https://orcid.org/0000-0002-8510-7055, Court, Jonathan B., Hayes, Anthony Joseph, Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 and Coogan, Michael Peter 2011. A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chemical Communications 47 (11) , pp. 3096-3098. 10.1039/c1cc10141b

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Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Chemistry
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Last Modified:	05 Nov 2022 15:04
URI:	https://orca.cardiff.ac.uk/id/eprint/22276

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