Multiphoton microscopy based on four-wave mixing of colloidal quantum dots

Masia, Francesco ORCID: https://orcid.org/0000-0003-4958-410X, Langbein, Wolfgang Werner ORCID: https://orcid.org/0000-0001-9786-1023 and Borri, Paola ORCID: https://orcid.org/0000-0002-7873-3314 2008. Multiphoton microscopy based on four-wave mixing of colloidal quantum dots. Applied Physics Letters 93 (2) , 021114. 10.1063/1.2959737

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Abstract

We demonstrate a novel multiphoton imaging modality based on the detection of four-wave mixing (FWM) from colloidal nanoparticles. This third-order signal is excited and detected in resonance with the ground-state excitonic transition of CdSe/ZnS quantum dots. We measure transversal and axial resolutions of 140 and 590 nm, respectively, significantly improved compared to the one-photon diffraction limit. The coherent FWM signal is detected using a heterodyne technique which rejects incoherent background for improved image contrast compared to fluorescence methods. As sensitivity limit, we estimate a minimum number of 10 dots/√HZ detectable in the focal volume.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Schools > Physics and Astronomy
Subjects:	Q Science > Q Science (General) Q Science > QC Physics
Publisher:	American Institute of Physics
ISSN:	0003-6951
Last Modified:	14 May 2023 03:41
URI:	https://orca.cardiff.ac.uk/id/eprint/22326

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