Systemic lactose intolerance: a new perspective on an old problem

Matthews, Stephanie Beatrix, Waud, J. P., Roberts, Andrew Glyn and Campbell, Anthony Keith 2005. Systemic lactose intolerance: a new perspective on an old problem. Postgraduate Medical Journal 81 (953) , pp. 167-173. 10.1136/pgmj.2004.025551

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Abstract

Intolerance to certain foods can cause a range of gut and systemic symptoms. The possibility that these can be caused by lactose has been missed because of “hidden” lactose added to many foods and drinks inadequately labelled, confusing diagnosis based on dietary removal of dairy foods. Two polymorphisms, C/T13910 and G/A22018, linked to hypolactasia, correlate with breath hydrogen and symptoms after lactose. This, with a 48 hour record of gut and systemic symptoms and a six hour breath hydrogen test, provides a new approach to the clinical management of lactose intolerance. The key is the prolonged effect of dietary removal of lactose. Patients diagnosed as lactose intolerant must be advised of “risk” foods, inadequately labelled, including processed meats, bread, cake mixes, soft drinks, and lagers. This review highlights the wide range of systemic symptoms caused by lactose intolerance. This has important implications for the management of irritable bowel syndrome, and for doctors of many specialties.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology
Publisher:	BMJ Publishing Group
ISSN:	0032-5473
Last Modified:	05 Jun 2017 02:58
URI:	https://orca.cardiff.ac.uk/id/eprint/22477

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