Regulation of neural process growth, elaboration and structural plasticity by NF-κB

Gutierrez, Humberto ORCID: https://orcid.org/0000-0002-5021-8636 and Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176 2011. Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends in Neurosciences 34 (6) , pp. 316-325. 10.1016/j.tins.2011.03.001

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Abstract

The nuclear factor-kappa B (NF-κB) family of transcription factors has recently emerged as a major regulator of the growth and elaboration of neural processes. NF-κB signaling has been implicated in controlling axon initiation, elongation, guidance and branching and in regulating dendrite arbor size and complexity during development and dendritic spine density in the adult. NF-κB is activated by a variety of extracellular signals, and either promotes or inhibits growth depending on the phosphorylation status of the p65 NF-κB subunit. These novel roles for NF-κB, together with recent evidence implicating NF-κB in the regulation of neurogenesis in the embryo and adult, have important implications for neural development and for learning and memory in the mature nervous system.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	Review
Publisher:	Elsevier
ISSN:	0166-2236
Related URLs:	http://www.cell.com/trends/neurosciences... http://www.ncbi.nlm.nih.gov/pmc/articles... http://www.ncbi.nlm.nih.gov/pubmed/21459...
Last Modified:	19 Oct 2022 09:53
URI:	https://orca.cardiff.ac.uk/id/eprint/22565

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