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Regulation of neural process growth, elaboration and structural plasticity by NF-κB

Gutierrez, Humberto and Davies, Alun M. 2011. Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends in Neurosciences 34 (6) , pp. 316-325. 10.1016/j.tins.2011.03.001

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The nuclear factor-kappa B (NF-κB) family of transcription factors has recently emerged as a major regulator of the growth and elaboration of neural processes. NF-κB signaling has been implicated in controlling axon initiation, elongation, guidance and branching and in regulating dendrite arbor size and complexity during development and dendritic spine density in the adult. NF-κB is activated by a variety of extracellular signals, and either promotes or inhibits growth depending on the phosphorylation status of the p65 NF-κB subunit. These novel roles for NF-κB, together with recent evidence implicating NF-κB in the regulation of neurogenesis in the embryo and adult, have important implications for neural development and for learning and memory in the mature nervous system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Review
Publisher: Elsevier
ISSN: 0166-2236
Related URLs:
Last Modified: 16 Oct 2017 14:34

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