In utero exposure to vigabatrin: No indication of visual field loss

Lawthom, Charlotte, Smith, Philip E. M. ORCID: https://orcid.org/0000-0003-4250-2562 and Wild, John Millington ORCID: https://orcid.org/0000-0003-3019-3889 2009. In utero exposure to vigabatrin: No indication of visual field loss. Epilepsia 50 (2) , pp. 318-321. 10.1111/j.1528-1167.2008.01700.x

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Abstract

The purpose of the study was to determine whether in utero exposure to vigabatrin caused visual field loss. Three mothers with four children who had been exposed to vigabatrin in utero and who were subsequently formula fed were identified. All seven individuals underwent perimetry and imaging of the retinal nerve fiber layer (RNFL). All individuals yielded reliable outcomes to perimetry and RNFL images of acceptable quality. Two of the three mothers exhibited vigabatrin-attributed visual field loss and an abnormally attenuated RNFL. The third exhibited an upper left quadrantanopia, consistent with previous temporal lobe surgery, and a normal RNFL. All four children yielded normal visual fields and RNFL thicknesses. The presence of the normal findings for the children is reassuring and, if representative, suggests a lack of vigabatrin visual toxicity and therefore obviates the need for ophthalmological examination of those exposed to vigabatrin prenatally.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Optometry and Vision Sciences Postgraduate Medical and Dental Education
Subjects:	R Medicine > RE Ophthalmology R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords:	Vigabatrin; Visual field loss; Retinal nerve fiber layer thinning; Prenatal exposure
Publisher:	Wiley
ISSN:	0013-9580
Last Modified:	19 Oct 2022 09:56
URI:	https://orca.cardiff.ac.uk/id/eprint/22733

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