Hyposmia in progressive supranuclear palsy

Silveira-Moriyama, Laura, Hughes, Graham, Church, Alistair, Ayling, Hilary, Williams, David R., Petrie, Aviva, Holton, Janice, Revesz, Tamas, Kingsbury, Ann, Morris, Huw Rees, Burn, David J. and Lees, Andrew J. 2010. Hyposmia in progressive supranuclear palsy. Movement Disorders 25 (5) , pp. 570-577. 10.1002/mds.22688

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Abstract

Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson’s disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r 5 0.44, P 5 0.006) but not disease duration (P 5 0.6), motor subscale of the Unified Parkinson’s Disease Rating Scale (P 5 0.2), or Frontal Assessment Battery (P 5 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Parkinson’s disease; postmortem analysis; UPSIT; smell; olfaction
Publisher:	John Wiley & Sons
ISSN:	0885-3185
Last Modified:	19 Mar 2016 22:39
URI:	https://orca.cardiff.ac.uk/id/eprint/22896

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