Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life and wellbeing in stages 0 to III breast cancer: a randomized, controlled trial

Hoffman, Caroline J., Ersser, Steven J., Hopkinson, Jane B. ORCID: https://orcid.org/0000-0002-3915-9815, Nicholls, Peter G., Harrington, Julia E. and Thomas, Peter W. 2012. Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life and wellbeing in stages 0 to III breast cancer: a randomized, controlled trial. Journal of Clinical Oncology 30 (12) , pp. 1335-1342. 10.1200/JCO.2010.34.0331

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Abstract

Purpose To assess the effectiveness of mindfulness-based stress reduction (MBSR) for mood, breast- and endocrine-specific quality of life, and well-being after hospital treatment in women with stage 0 to III breast cancer. Patients and Methods A randomized, wait-listed, controlled trial was carried out in 229 women after surgery, chemotherapy, and radiotherapy for breast cancer. Patients were randomly assigned to the 8-week MBSR program or standard care. Profile of Mood States (POMS; primary outcome), Functional Assessment of Cancer Therapy–Breast (FACT-B), Functional Assessment of Cancer Therapy–Endocrine Symptoms (FACT-ES) scales and the WHO five-item well-being questionnaire (WHO-5) evaluated mood, quality of life, and well-being at weeks 0, 8, and 12. For each outcome measure, a repeated-measures analysis of variance model, which incorporated week 0 measurements as a covariate, was used to compare treatment groups at 8 and 12 weeks. Results There were statistically significant improvements in outcome in the experimental group compared with control group at both 8 and 12 weeks (except as indicated) for POMS total mood disturbance (and its subscales of anxiety, depression [8 weeks only], anger [12 weeks only], vigor, fatigue, and confusion [8 weeks only]), FACT-B, FACT-ES, (and Functional Assessment of Cancer Therapy subscales of physical, social [8 weeks only], emotional, and functional well-being), and WHO-5. Conclusion MSBR improved mood, breast- and endocrine-related quality of life, and well-being more effectively than standard care in women with stage 0 to III breast cancer, and these results persisted at three months. To our knowledge, this study provided novel evidence that MBSR can help alleviate long-term emotional and physical adverse effects of medical treatments, including endocrine treatments. MBSR is recommended to support survivors of breast cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RT Nursing
Publisher:	American Society of Clinical Oncology
ISSN:	0732-183X
Last Modified:	19 Oct 2022 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/22904

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