Psychiatric disorders, myoclonus dystonia, and the epsilon-sarcoglycan gene: a systematic review

Peall, Kathryn J. ORCID: https://orcid.org/0000-0003-4749-4944, Waite, Adrian James, Blake, Derek J. ORCID: https://orcid.org/0000-0002-5005-4731, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Morris, Huw Rees 2011. Psychiatric disorders, myoclonus dystonia, and the epsilon-sarcoglycan gene: a systematic review. Movement Disorders 26 (10) , pp. 1939-1942. 10.1002/mds.23791

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Abstract

Background: Mutations in the maternally imprinted epsilon-sarcoglycan gene occur in 30%–50% of myoclonus-dystonia cases. Psychiatric symptoms, particularly obsessive-compulsive disorder, have been described in some patients. Methods: We systematically reviewed 22 reports of psychiatric symptoms in myoclonus-dystonia, dividing individuals according to clinical and mutation status. Results: Clinically manifesting mutation carriers demonstrated an excess of psychiatric disorders compared with nonmutation carriers (P < .001). No differences were seen between non-motor-manifesting carriers and nonmutation carriers with the exception of alcohol excess/dependence, higher in non-motor-manifesting carriers. Conclusions: The results confirm the association of epsilon-sarcoglycan gene mutations with psychiatric disease and suggest a possible separation of the motor and psychiatric effects.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	myoclonus dystonia, epsilon-sarcoglycan, SGCE, DYT11, psychiatric disorders
Publisher:	Wiley
ISSN:	0885-3185
Last Modified:	19 Oct 2022 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/22922

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